| Acronym | Definition |
|---|
| MDF | Medium Density Fiberboard |
| MDF | Main Distribution Frame |
| MDF | myocardial depressant factor |
| MDF | Medium Density Fiber |
| MDF | Main Distribution(al) Facility |
| MDF | Magyar Demokrata Fórum (Hungarian Democratic Forum) |
| MDF | Mule Deer Foundation |
| MDF | Manic Depression Fellowship (UK) |
| MDF | Marketing Development Funds |
| MDF | Master Data File |
| MDF | My Dear Friend |
| MDF | Macular Degeneration Foundation |
| MDF | Multi-Density Fiberboard (construction) |
| MDF | Magic Defense (video gaming) |
| MDF | Macro-Defect-Free |
| MDF | Mission Data File |
| MDF | Made the Cut, Did Not Finish (PGA golf tournament) |
| MDF | Mild Detonating Fuse |
| MDF | Micro Data Format |
| MDF | Mineral Development Fund (Namibia) |
| MDF | Manipulator Development Facility |
| MDF | Monitor Definition File |
| MDF | Multimedia Description Framework |
| MDF | Meta Data Framework |
| MDF | Microphone Data File |
| MDF | Meta Data Processing Framework |
| MDF | Multiplicative Decrease Factor |
| MDF | Main Defense Forces (NATO) |
| MDF | Mux Data Frame |
| MDF | Multisensor Data Fusion |
| MDF | Mercados de Futuros (Guatemala) |
| MDF | Minimum Detectable Flux |
| MDF | Mirror Description Format |
| MDF | Methanol Dehydrogenase |
| MDF | Main Data Feed |
| MDF | Monopulse Direction Finding |
| MDF | Mammalian Development Facility |
| MDF | Main Distribution Frequency |
| MDF | Morte Di Fame (Italian: Dying of Hunger) |
| MDF | Maritime Defense Force |
| MDF | Mason Dixon Farms, Inc. (Gettysburg, Pennsylvania) |
| MDF | Manual Dial Facility |
| MDF | Material Discrepancy Form |
| MDF | Materiel Distribution Forecasting |
| MDF | Mission Data Folders |
| MDF | Multiband Direction Finder |
| MDF | Mendelsohn Difference Family |
| MDF | Main Debris Field |
| MDF | Maryland Deathfest (music festival) |