Previous studies showed that NO generation by eNOS induces vasodilatation which might depress the hypoxic damage, while, conversely, elevated nNOS
production results in neuronal injury.
differs from the other two mammalian isoforms, eNOS and iNOS by an additional ~300 residue N-terminal extension mostly involved in subcellular targeting, This N-terminus extension comprises a PDZ domain (Bredt et al, 1991).
encontraron que la administracion de donadores de NO bloquea el efecto inducido por el antagonista glutamatergico PCP (un modelo experimental de esquizofrenia), mientras que los efectos de este farmaco se potencian en presencia de un inhibidor de la nNOS
No association between Parkinson's disease and three polymorphisms in the eNOS, nNOS
, and iNOS genes.
In contrast, the activity of citrate synthase (CS), a marker of the mitochondrial tricarboxylic aid cycle, in skeletal muscle, as well as that in brain, kidney, and liver, in mice lacking nNOS
is higher than that in wild-type mice (Schild et al.
Variables Normal lung tissue Cellular SSc Septal nNOS
Monoclonal rabbit antibodies for AQP2-3 (Chemicon, Temecula, CA; 1:2000, 1:1000, and 1:1000, respectively), eNOS and nNOS
(Santa Cruz, CA; 1:1000 and 1:1000, respectively), and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) (Sigma, St.
One of these "helper" molecular compounds is nNOS
, which produces nitric oxide that can keep muscle cells healthy after exercise.
La PSD95 une los receptores de glutamato N-Metil-D-Aspartato (NMDA) a la nNOS
, lo que lleva a la produccion de oxido nitrico (NO).
17 Beta-estradiol regulates nNOS
and eNOS activity in the hippocampus.
While the NO produced by eNOS and nNOS
takes role in fundamental physiologic processes like vascular hemostasis and neurotransmission, the NO produced by iNOS has role in regulation of intercellular matrix, and proinflammatory processes like cell death and tissue injury.
Following on our recent report describing the kinetics of CaM-NOS binding, present results describe binding of nNOS
and eNOS to Calmodulin-Troponin C (CaM.