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Infection with frog virus 3 (FV3), the type species of the genus Ranavirus, results in edema, hemorrhage, and necrosis of lymphoid tissue, hematopoietic tissue, liver, spleen, and renal tubules (3,5); mortality rates in free-ranging amphibians are >90% (6). For the most part, nuclear pleomorphism, increased mitotic figures (>2 per high-power field), and necrosis are uncommon. They and others had shown earlier that free radical damage can lead to cellular necrosis and apoptosis. |
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