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Another approach has used the licensed HIV protease inhibitors nelfinavir and ritonavir, which in addition to blocking the cleavage of HIV propeptides have direct antiapoptotic effects (31). ROCHE, a Swiss pharmaceuticals company, slashed the price of its blockbuster AIDS drug Nelfinavir by 40%. But Tyson immediately began taking her prescription of Combivir, whose components AZT and 3TC have caused fetal deformities and cancers in laboratory animals, and she was given the protease inhibitor nelfinavir, whose effects in human pregnancy have yet to be fully understood. |
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