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Neuropathological alterations involved neuronal loss and neurofibrillary tangles in the basal ganglia, brain stem, and cerebellum. Today, he says, it's most likely that there are two primary causes of dementia: an Alzheimer's disease type "pathology," represented by the neurofibrillary tangles and senile plaques of the disease, and vascular dementia, resulting from significant changes in blood vessels in the brain. Neurofibrillary tangles are the second hallmark of Alzheimer's. |
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