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Western blot analysis of selected proteins in the brain such as glial fibrillary acidic protein (GFAP), synaptophysin and neurofilament (NF) at increasing PMI and quantitation (normalized against tubulin) showed no significant change in GFAP signal in FC, CB and CD, while SN revealed a significant increase in GFAP signal (Fig.
Whether these unusual neurofilament deposits were a cause or a consequence of motor neurons dying has been a mystery.
For example, neurofilament staining will highlight entrapped axons in the middle of an infiltrative tumor.
Proteins identified Accession (a) Downregulated proteins 1 PRAME family member 7 PRAM7_HUMAN 2 [alpha]-1B-glycoprotein precursor A1BG_HUMAN 3 Keratin, type II cytoskeletal 1 K2C1_HUMAN 4 Neurofilament triplet L protein NFL_HUMAN 5 Vitamin D-binding protein VTDB_HUMAN precursor 6 Protease C1 inhibitor IC1_HUMAN precursor 7 Keratin, type I cytoskeletal 10 K1C10_HUMAN 8 Complement factor B CFAB_HUMAN precursor 9 Complement C1r C1R_HUMAN subcomponent precursor 10 Transthyretin precursor TTHY_HUMAN 11 Zinc finger protein 792 ZN792_HUMAN 12 Kininogen-1 precursor KNG1_HUMAN Upregulated proteins 1 Complement factor H CFAH_HUMAN precursor 2 Apolipoprotein C-III precursor APOC3_HUMAN 3 [[alpha].
Santa Cruz, CA, USA), neurofilament (MAB1615; Chemicon), cardiac troponin 1 (MAB3152; Chemicon), and [alpha] fetoprotein (V7049; Biomeda Corp.
Western blot and immunoprecipitation analysis confirmed neurofilament heavy chain to be a major target of CEP-modification.
The investigators found that 10 days after fighting in a match, the boxers had a fourfold higher level of neurofilament light (NFL), which indicates neuronal injury, than did control subjects.
Clinical and demographic findings can help make distinctions, as can pertinent immunohistochemical reactions to synaptophysin, chromogranin, neuron-specific enolase (NSE), neurofilament protein (NFP), S-100 protein, keratin, CD45RB, desmin, CD99, and HMB45.
Increased cerebrospinal fluid levels of neurofilament protein in progressive supranuclear palsy and multiple system atrophy.
16,17) Antibodies to neurofilament protein, which presumably stain the intratumoral axons in neurofibroma, stain positive in benign nerve sheath tumors but are not useful in differentiating neurofibromas from Schwannomas.
In response to serum starvation or treatment with retinoic acid (RA) or dibutyryl cyclic AMP, N2a cells undergo neuronal differentiation characterized by cell cycle arrest, neurite outgrowth, and up-regulation of neurofilament (NF) proteins (Dasgupta and Milbrandt 2007).
The interesting work carried out by Savory and his co-workers on the quantitation of Al in the brain and spinal cord and its effects on neurofilament protein expression and phosphorylation provided new evidence for the involvement of Al in AD (42).