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The new coating material staves off clotting because its copper ions catalyze the production of nitric oxide in the blood, says Mark Meyerhoff of the University of Michigan in Ann Arbor. This mechanism is centered on the activation of N-methyl-D-aspartate (NMDA) receptors by organic solvents producing elevated nitric oxide and peroxynitrite, leading in turn to increased stimulating of and hypersensitivity of NMDA receptors. Nitric oxide (NO) in exhaled breath is produced primarily by the upper respiratory airway mucosa. |
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