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2,3) The enzyme responsible for the S-oxidation of SCMC to SCMC sulfoxide has been reported to be phenylalanine hydroxylase. After absorption, they are then used, metabolized, and/or excreted by the body following the same metabolic pathways as when consumed through the ordinary diet: aspartate is transformed into alanine plus oxaloacetate (Stegink 1984); phenylalanine is transformed mainly into tyrosine and, to a smaller extent, phenylethylamine and phenylpyruvate (Harper 1984); and methanol is transformed into formaldehyde and then to formic add (Opperman 1984). I have also supplemented with the essential amino acids--methionine, phenylalanine, tryptophan, leucine, isoleucine, valine, lysine, and threonine--but only after the previously listed supplements have been given. |
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