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It has been suggested that more severe illness may develop in English springer spaniels with suspected phosphofructokinase deficiency and persons with glucose 6-phosphate dehydrogenase deficiency when infected with R. X] [+ or -] SD]), lower oxidative enzyme activity (ie, citrate synthase, 3-hydroxyacyl-CoA dehydrogenase), and higher activity of the glycolytic enzyme, phosphofructokinase, compared with that of matched controls. For example, phosphofructokinase, an enzyme purified from rabbit skeletal muscle, is completely inactivated by one dehydration process. |
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