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In addition, trials have shown that aliskiren does not elevate plasma renin activity, a benefit that suggests the drug may be less likely than existing treatments to cause end-organ damage. Removal of the negative feedback of angiotensin II causes a 2- to 3-fold rise in plasma renin activity and consequent rise in angiotensin II plasma concentration in hypertensive patients. Removal of the negative feedback of angiotensin II causes a 2- to 3-fold rise in plasma renin activity and consequent rise in angiotensin II plasma concentration in hypertensive patients. |
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