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The ALAD gene codes for the enzyme [delta]-aminolevulinic acid dehydratase (ALAD), which catalyzes the second step of heme synthesis involving the condensation of two molecules of aminolevulinic acid (ALA) to form porphobilinogen. The affinity of human erythrocyte porphobilinogen synthase for Zn2+ and Pb2+. These include aminolevulinate (ALA) dehydratase, porphobilinogen deaminase (hydroxymethylbilane synthase), and uroporphyrinogen decarboxylase in spleen and ALA synthase in liver. |
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