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For example, Frassetto's team recently gave 170 postmenopausal women either potassium bicarbonate or a placebo for up to three years. By utilizing potassium bicarbonate as a localized buffer, DBT enables diclofenac to enter the bloodstream more quickly, resulting in a faster rate of drug absorption and increased peak plasma concentrations while not increasing the total amount of drug exposure for the patient compared to currently marketed reference drug, Cataflam([R]). Shown to enhance the pharmacokinetics of diclofenac, IRT uses potassium bicarbonate to create a dynamic buffering environment in the gastrointestinal tract that helps facilitate a more rapid and consistent absorption of diclofenac. |
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