prf1

AcronymDefinition
prf1Protein Release Factor 1
References in periodicals archive ?
Characterisation of diverse PRF1 mutations leading to decreased natural killer cell activity in North American families with haemophagocytic lymphohistiocytosis.
A665G mutation in PRF1 in a Turkish infant with familial hemophagocytic lymphohistiocytosis.
Varios estudios han revelado que el tratamiento de celulas T normales con 5-azaC (inhibidor de metilacion de DNA 5-azacytidina) induce la sobre expresion de genes sensibles a la metilacion, como TNFSF7 (CD70), PRF1 (perforina) y CD40LG (CD40L), mismos que se encuentras hipometilados en celulas T de pacientes con lupus.
Otros genes sensibles a la metilacion son el CD70, una molecula coestimuladora de celulas B, sobreexpresada en celulas T, asi como PRF1 la cual codifica para una proteina formadora de poros expresada principalmente por las celulas natural killer y linfocitos CD8+.
We also evaluated T cell- and NK cell-related genes, including CD3D [CD3d molecule, delta (CD3-TCR complex)], CD69 (CD69 molecule), PRF1 [perforin 1 (pore forming protein)], GNLY (granulysin), CCR3 [chemokine (C-C motif) receptor 3], KLRK1 (killer cell lectin-like receptor subfamily K, member 1), IDO1 (indoleamine 2,3-dioxygenase 1), and KLRD1 (CD94) (killer cell lectin-like receptor subfamily D, member 1).
CD3D and PRF1 expression showed the most pronounced differences (Fig.
This group consisted of the TNF, IL1B, CD3D, and PRF1 genes.
Cytokine-encoding genes TNF and IL1B and the T cell- and NK cell-related genes CD3D and PRF1 were differentially expressed in a group of patients who developed postoperative sepsis at a median of 5 days before the clinical diagnosis of sepsis.
Characterization of PRF1, STX11 and UNC13D genotype-phenotype correlations in familial hemophagocytic lymphohistiocytosis.