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Through its interaction with VEGFR-2 in the endothelial cells, VEGF also enhances the production of nitric oxide and prostacyclin and increases vascular permeability (Murohara et al. These include prostaglandin analogs such as prostacyclin and low-dose inhaled nitric oxide. 3) Another agent, the prostacyclin analog iloprost, has potent vasodilatory and antiplatelet effects. |
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