| Acronym | Definition |
|---|
| RPG | Role Playing Game(s) |
| RPG | Rocket-Propelled Grenade |
| RPG | Rocket-Powered Grenade |
| RPG | Rebounds Per Game (basketball statistic) |
| RPG | Report Program Generator |
| RPG | Report Generator |
| RPG | Regional Planning Guidance |
| RPG | Rassemblement du Peuple de Guinée (French: Rally of the People of Guinea) |
| RPG | Risk Purchasing Group |
| RPG | Rassemblement Pour le Gabon (French: Rally for Gabon) |
| RPG | Rounds Per Gun (aircraft) |
| RPG | Random Plasma Glucose |
| RPG | Rééducation Posturale Globale (French: Global Posture Reeducation) |
| RPG | Retrograde Pyelogram |
| RPG | Reflection Phase Grating |
| RPG | Radar Product Generator |
| RPG | Recommended Practices Guide |
| RPG | Rotary Pulse Generator (electronics) |
| RPG | Red Porgy (FAO fish species code) |
| RPG | Reasonable and Probable Grounds |
| RPG | Ruchnoy Protivotankovy Granatomyot (Russian: Rocket Propelled Grenade) |
| RPG | Renegade Programming Group (est. 1991) |
| RPG | Relapse Prevention Group |
| RPG | Radiation Protection Guide |
| RPG | Radioisotope Power Generator |
| RPG | Resistance Protein Gene |
| RPG | Rate Per Gallon |
| RPG | Rape Prevention Glasses (military slang) |
| RPG | Reuse Planning Group |
| RPG | Resource Protection Group |
| RPG | Repeating Plasma Gun (Star Wars) |
| RPG | Remote Product Generator |
| RPG | Respiratory Pattern Generator |
| RPG | Ram Prasad Goenka (Enterprises; India) |
| RPG | Rapid Programme Generation (AS/400) |
| RPG | Research Planning Group/Guide |
| RPG | REFORGER Planning Group |
| RPG | Running Power Generation (Mode) |
| RPG | Routine Production Group |
| RPG | Research Policy Group (various locations) |
| RPG | Research Program Grant (various organizations) |
| RPG | Rules for Posting (forums) |
| RPG | Registry Player and Game |
| RPG | Research Post Graduate (various universities) |