sICAM-1Soluble Inter-cellular Adhesion Molecule-1
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The level of sICAM-1 is elevated in hyperlipidemic individuals and associated with high cardiovascular risk (Karasek et al.
Circulating levels of sICAM-1 and sVCAM-1 have been predictive of CVD risk in cohort studies (Blankenberg et al.
The serum was separated for the testing of estradiol and sICAM-1 and stored at -80C.
Serum concentrations of sICAM-1, sVCAM-1 and E-selectins were determined with sandwich enzyme-linked immunosorbent (ELISA) assays (Bender MedSystems Diagnostics GmbH, Vienna, Austria) according to the manufacturer's recommendations.
Among the inflammatory mediators associated to the risk of cardiovascular events we find serum amyloid A, sICAM-1, IL-6, homocysteine, total cholesterol, LDL cholesterol, and C-reactive protein (6, 7), which increase in patients with periodontitis inducing pro-coagulation and alterations in lipid metabolism, which can increase risks of cardiovascular events.
Effects of aerobic and resistance trainings on serum sICAM-1 and lipids in owerweight women, Sport and Biomotor Sciences, 4: 77-87.
sICAM-1 concentrations significantly decreased after 6 hours of CW and CM interventions and E-selectin only decreased after CW intervention.
They include markers of inflammation (eg hsCRP, sICAM-1, IL-6), altered thrombosis (eg tPA/PAI-1, fibrinogen, homocysteine), oxidative stress (oxidized LDL, F2-isoprostanes) and altered lipids [eg lipoprotein (a), LDL particle size] (Ridker et al.
Las concentraciones de MCP-1, sP-selectin, sVCAM-1 y sICAM-1 se comportaron igual.
Additionally, less frequent preventive care was associated with higher levels of sICAM-1 and a trend toward higher tPAI-1.