| Acronym | Definition |
|---|
| SMI | Safe Motherhood Initiative |
| SMI | Saint Matthew Island (Alaska) |
| SMI | Samos Island, Greece (Airport Code) |
| SMI | Sample Matrix Inversion |
| SMI | Sample Matrix Inverter |
| SMI | Saturday Morning Inspection |
| SMI | School Meals Initiative for Healthy Children (USDA) |
| SMI | Scientology Missions International |
| SMI | Secret of Monkey Island |
| SMI | Security Management Information |
| SMI | Security Management Infrastructure |
| SMI | Self-Mounting floppy disk Image (Mac OS File Extension) |
| SMI | Sending Module ID |
| SMI | Senior Marine Instructor (USMC JROTC) |
| SMI | Senior Military Instructor (Army ROTC) |
| SMI | Serial Management Interface |
| SMI | Serious Mental Illness |
| SMI | Service Management Interface |
| SMI | Severely Mentally Ill |
| SMI | Severely Mentally Impaired |
| SMI | Shared Memory Interface |
| SMI | Ship Manpower Information |
| SMI | Ship Modification Instruction |
| SMI | Side Mount Intercooler (automotive turbo systems) |
| SMI | Silent Myocardial Infarction |
| SMI | Simple Matrix Inversion |
| SMI | Sisters of Mary Immaculate (religious order) |
| SMI | Small Medium Industry |
| SMI | Smart Money Index |
| SMI | Society for Molecular Imaging (Kerrville, TX) |
| SMI | Soil Moisture Index |
| SMI | Soldier/Machine Interface |
| SMI | Southern Military Institute |
| SMI | Specialty Manufacturing Inc (San Diego, CA) |
| SMI | Speedway Motorsports, Inc. |
| SMI | Sperry Marine Inc. |
| SMI | Sports Management International LLC |
| SMI | Spring Manufacturers Institute |
| SMI | Standard Multilayer Software Image (Cisco) |
| SMI | Stanford Medical Informatics |
| SMI | Storage Management Initiative (HP) |
| SMI | Structural Mode Interaction |
| SMI | Structure of Management Information |
| SMI | Structured Management Information |
| SMI | Structured Materials Industries, Inc. |
| SMI | Subsystem Multiplicity Indicator (SS7 SCCP) |
| SMI | Sudden Money Institute |
| SMI | Sun Microsystems, Inc. |
| SMI | Supplemental Medical Insurance (US Medicare Part B) |
| SMI | Supplementary Medical Insurance |
| SMI | Supplier Managed Inventory (supply chain management) |
| SMI | Supply Management Inspection |
| SMI | Surface Measuring Instrument |
| SMI | Sustainable Minerals Institute (Brisbane, Australia) |
| SMI | Swiss Market Index (trademark of SWX Swiss Exchange) |
| SMI | Swiss Meteorological Institute |
| SMI | System Management Interrupts |
| SMI | System Monitoring Interface |
| SMI | Sequelink Middleware Interface |
| SMI | Shared Multidimensional Information |
| SMI | Single Mode Fiber Intermediate Range |
| SMI | Special Message Identifier |
| SMI | Standard Multilayer Image |
| SMI | State Management Interface |
| SMI | Storage Management Interface |
| SMI | Suzuki Maruti India |
| SMI | Synchronized Multimedia Integration |
| SMI | Systems and Materials for Information Storage |