| Acronym | Definition |
|---|
| SPN | Symantec Protection Network |
| SPN | Specifications (TMINS) |
| SPN | Supernatural (TV show) |
| SPn | Streptococcus Pneumoniae |
| SPN | Society of Pediatric Nurses |
| SPN | solitary pulmonary nodule |
| SPN | Substitution-Permutation Network |
| SPN | Stochastic Petri Net |
| SPN | Social Psychology Network |
| SPN | Sialophorin |
| SPN | Sindicato dos Professores do Norte (Northern Teachers' Union; Portugal) |
| SPN | Service Provider Name |
| SPN | Service Provider Network (Los Angeles, CA HIV prevention and care) |
| SPN | Specific Procurement Notice |
| SPN | Shortest Process Next (scheduling algorithm) |
| SPN | Service Principle Name |
| SPN | Secure Private Network |
| SPN | Surat Perbendaharaan Negara (Indonesia - Treasury Bills) |
| SPN | Successful Practices Network |
| SPN | Smart Protection Network |
| SPN | Shared Processing Network |
| SPN | Satellite Program Network |
| SPN | Suspect Parameter Number |
| SPN | Signal-Plus-Noise |
| SPN | Student Practical Nurse |
| SPN | Shipment Performance Notice |
| SPN | Safe Petri Net |
| SPN | Standard Precision Navigator |
| SPN | South Pacific Division-San Francisco District (USACE) |
| SPN | Stretch Performance Network (oil and gas industry) |
| SPN | Shift-Pulse Network |
| SPN | Servicios Postales Nacionales SA (Spanish, Colombia) |
| SPN | Software Project Notebook |
| SPN | Signal Processor/Processing Network |
| SPN | Sequential Phase Number |
| SPN | Simplest Possible Number |
| SPN | Shipboard Radar Navigation |
| SPN | Sponsor Program Number |
| SPN | Start Production Notice / Stop Production Notice |
| SPN | Simple Purchasing Network |
| SPN | Saipan, Northern Mariana Islands - Saipan International Northern Mariana Isles (Airport Code) |
| SPN | Switch Panel Network |
| SPN | Strategic Partnership Network (finance) |
| SPN | Subliminal Psychic Network (band) |