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STZ |
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In the study, 24 mice received five daffy injections of a diabetes-inducing chemical known as streptozotocin. In these studies, non human primates are treated by an agent called streptozotocin (STZ) which induces them to become diabetic and consequently dependent upon administration of exogenous insulin for the maintenance of reasonable blood sugar levels. N-nitroso compounds such as the nitrosamides streptozotocin and N-nitrosomethylurea have toxic effects on pancreatic [Beta]-cells in animals; streptozotocin is used as a model compound to induce type 1 diabetes in rats (12,13). |
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