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Due to a progressive loss of substantia nigra neurons that produce dopamine, neurotransmitter imbalances occur in the basal ganglia. VISIBLE LOSSES Like a time-lapse series of snapshots, repeated imaging of the substantia nigra can both track the disease's progression and monitor the effects of treatment. The major pathologic feature of PD is the profound loss of pigmented neurons, mainly in the pars compacta of the substantia nigra (SN). |
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