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A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis. Brittain and her colleagues found that the integrin molecules could bind a cell to a vessel wall by attaching to thrombospondin there. [53-57] Link protein, as discussed above, is required to stabilize the PG aggregates in the cartilage matrix, fibromodulin interacts with various matrix components and controls collagen fibril formation, osteopontin sequesters calcium and promotes tissue calcification, and thrombospondin plays a role in cell attachment. |
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