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Inorganic heavy metals have been known for a long time to be nephrotoxic at relatively high levels of exposure, with numerous reports of tubulointerstitial nephritis possibly leading to renal failure, in most cases linked to high occupational or environmental exposure (Fowler 1996). Renal biopsy 17 days post exposure showed acute tubulointerstitial nephritis (Figure 2A), which is reported to be the most characteristic renal lesion observed in leptospirosis (23,24). |
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