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Related to ubiquitin: Ubiquitin proteasome pathway, ubiquitin C
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References in periodicals archive ?
Now the ubiquitin E3 ligase itself is just one specific kind of ubiquitin ligase whose job it is to add some of these subunits together under specific cellular conditions.
Proteologics is a leading drug discovery company focusing on small molecule inhibitors of the ubiquitin system.
If FUS staining is negative, the diagnosis is FTLD involving the ubiquitin proteasome system (FTLD-UPS), and more specifically, it may be associated with mutations in the CHMP2Ba gene (FTD-3) or possibly a FUS-negative sporadic FTLD-UPS.
In situations where resources and expertise in evaluating these types of cases are limited, using a single immunohistochemical stain for ubiquitin in combination with routine hematoxylin-eosin has been recommended.
The cylinder has proteolytic activity in its core that indiscriminately hydrolyses unfolded proteins fed into the cylinder by the caps, which identify proteins to be degraded by their ubiquitin signals.
Within cells, ubiquitin identifies and attaches to proteins that are ripe for degradation and removal.
Using the technique previously applied in the titin experiments, Fernandez pulled on one end of a gold-anchored ubiquitin molecule.
The two main components of this system are (1) three enzymes that add a small protein called ubiquitin onto substrate proteins destined for degradation, and (2) the proteasome, a rather large cellular particle composed of several smaller protein subunits, which executes the actual proteolysis.
Pigment-containing follicular epithelium has reduced thyroglobulin and ubiquitin immunoreactivity.
In addition, each antigen fragment is fused to the ubiquitin protein to increase antigen expression and target these antigens to the proteasome to enhance cytotoxic T lymphocyte (CTL) responses.
The Terada-Schatten team found that an infertile sperm tends to have a large formation of ubiquitin on its surface compared with healthier sperms.
com) aims to discover and develop novel medicines exploiting ubiquitin pathways.