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Role of ubiquitin conjugation in the rapid degradation of CYP2E1. With Mariano Carrion-Vazquez, also of Columbia, and others, Fernandez discovered a hidden weakness by which ubiquitin can be unfolded with much less force than by simply pulling on one of the molecule's two ends. Technion Professors Avram Hershko and Aaron Ciechanover, whose research has been funded by ICRF for 22 years, received the 2004 Nobel Prize in chemistry for discovering a process that lets cells destroy unwanted proteins--the ubiquitin system. |
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