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Exposure to ionizing radiation (IR) produces several forms of cellular DNA damage, including formation of uracil, apurinic/apyrimidinic sites, 8-oxoguanine, single-strand breaks, and double-strand breaks (Heinloth et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications fur cancer and neuronal damage. Although proprietary, patented OBS chemistry is based on uracil, which is naturally present in the human body as one of the four building blocks of RNA nucleic acids. |
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