| Acronym | Definition |
|---|
| UP | Upper Peninsula (of Michigan) |
| UP | Used Part |
| UP | United Press |
| UP | University Press |
| UP | University Place (Washington) |
| UP | User Profile |
| UP | User Program |
| UP | Unit Price |
| UP | University of Pennsylvania |
| UP | University of Phoenix |
| UP | Upgrade Package |
| UP | Upper Division (degree plan) |
| UP | Urban Planning |
| UP | Ukraine |
| UP | University of Portland |
| UP | University of the Philippines |
| UP | University of Pittsburgh |
| UP | Utility Player |
| UP | United Party (Papua New Guinea) |
| UP | Union Pacific Corporation (US railroad) |
| UP | United Planet |
| UP | Universal Precautions (Centers for Disease Control) |
| UP | Unified Process |
| UP | University of Pretoria (South Africa) |
| uP | Microprocessor |
| UP | Unity Party |
| UP | United Provinces (India) |
| UP | Union Pacific Railroad Company |
| UP | Universidade do Porto (University of Oporto, Portugal) |
| UP | Unit Police (military) |
| UP | Uttar Pradesh (state in India) |
| UP | Uninterruptible Power |
| UP | Unit Personnel |
| UP | Universidad de Palermo (Spanish) |
| UP | United Personnel |
| UP | User Plane (Universal Mobile Telecommunications System) |
| UP | Upwind |
| UP | Universidad del Pacifico (Spanish: University of the Pacific, Peru) |
| UP | Universidad Panamericana (Guadalajara, Mexico) |
| UP | Under Provisions |
| UP | Université de Poitiers (French: University of Poitiers; France) |
| UP | Unsaturated Polyester |
| UP | UniProcessor |
| UP | Universiteit Van Pretoria (South Africa) |
| UP | Unsolicited Proposal |
| UP | Utgarde Pinnacle (World of Warcraft) |
| UP | Unión Popular (Spanish: Popular Union) |
| UP | Urban Pipeline (clothing) |
| UP | Uillean Pipes |
| UP | Utopia Planitia (Star Trek shipyard) |
| UP | Urticaria Pigmentosa |
| UP | User Priority |
| UP | Ulcerative Proctitis |
| UP | Uni-Processor |
| UP | Union Parishad |
| UP | Understanding Principles (Universal Foundation for Better Living) |
| UP | Uniform Population (sectorization method) |
| UP | Universität Passau (Germany) |
| UP | Université de Perpignan |
| UP | UniquePhones (website) |
| UP | Union of Labor (Poland) |
| UP | Utilities Privatization |
| UP | Unknown Precipitation (METAR precipitation) |
| UP | Unibersidad Ng Pilipinas (University of the Philippines) |
| UP | Underproof |
| UP | Umbral Plains (gaming, Everquest) |
| UP | Union Pétrolière |
| UP | Utopia Prime (gaming) |
| UP | Uncrossable Parallel (Half-Life modification) |
| UP | Unforgiven Promises (band) |
| UP | Unlimited Potential (various locations) |