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Newer studies are trying to correct mitochondrial depletion through the use of the supplement uridine, which has been shown effective in treating mitochondrial toxicity caused by d4T and AZT (zidovudine or Retrovir). The reasons for decreased thyroid hormones are not entirely clear because the proposed mechanisms--induction of thyroid-metabolizing uridine diphosphate-glucuronosyltransferase (UDP-GT) and competitive binding to serum transport proteins--are not sufficient to explain hormone reductions in certain animal models after exposure to PCBs (Kato et al. Mutations were noted in uridine kinase (gi29654198) in ST18, ST22, ST23, ST25, and ST29; in ompA-like transmembrane domain protein (gi29654257), in ST20; in rhodanese-like domain protein (gi29654263) in ST20 (the protein was longer by 2 amino acids); in dioxygenase (gi29654325) in ST21 and ST22; in hypothetical protein (gi29732244), in ST17. |
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