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Related to valproate: carbamazepine, Sodium valproate
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References in periodicals archive ?
The FDA cited data from the Neurodevelopmental Effects of Antiepileptic Drugs study, published in March 2013, which found that at age 6, children whose mothers had taken valproate products while pregnant had lower IQs, compared with those whose mothers took other antiepileptic drugs.
When the researchers ran the numbers, they found that prenatal valproate exposure was connected with an absolute risk for autism of 4.
More than one in 10 (12%; 6 out of 50) children whose mums had taken valproate alone during their pregnancy had a neurodevelopmental problem, as did one in seven (15%; 3 out of 20) of those whose mums had taken valproate with other drugs.
Valproate is, for some people, the only drug that can control their epilepsy, so the findings on dosage and the beneficial effects of folic acid could be useful.
In a multivariate analysis of the intent-to-treat sample of 310 children, IQ was lower among children exposed in utero to valproate compared with children of mothers who took other antiepileptic drugs (AEDs) during pregnancy.
Valproate is extensively conjugated to glucuronic acid, and more than half of an ingested dose is excreted in the urine as the glucuronide, along with smaller amounts of hydroxylated valproate metabolites and their glucuronide conjugates.
If manic symptoms are a prominent feature, consider using valproate 300 mg 2 x daily, increasing to 600 mg 2 x daily; use lower doses and monitor liver function tests if liver impairment is present.
Verification of the fetal valproate syndrome phenotype.
Professor of Clinical Neuropsychology at the university, Gus Baker, said "We looked at how exposure to sodium valproate and other anti-epilepsy drugs (AED) in the womb affected children's everyday life - in particular their IQ, memory and language abilities from one to six years of age.
The valproate children had IQ scores six to nine points lower by age 3, said the study's lead author, Dr Kimford Meador of Emory University.
The efficacy and safety of ABILIFY, used in combination with lithium or valproate for the treatment of patients with Bipolar I Disorder, were investigated during a 6-week multicentre, double-blind, randomized, placebo-controlled study involving 348 patients, followed by a 46-week open-label extension phase.