006

AcronymDefinition
006Alec Trevelyan (Goldeneye movie)
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BCIRG 006 randomized 3,222 patients with HER2-positive breast cancer and positive lymph nodes or other high-risk features to one of three treatment arms: a control regimen involving standard potent anthracycline-based chemotherapy with four cycles of doxorubicin and cyclophosphamide followed by four of docetaxel; the same regimen, plus 1 year of adjuvant trastuzumab starting concurrent with the docetaxel: or a year of trastuzumab starting at the outset of six cycles of docetaxel and carboplatin.
The major new cardiotoxicity finding in BCIRG 006 was that the asymptomatic decline in left ventricular ejection fraction known to be induced by trastuzumab in a substantial portion of patients, is far more persistent than previously reported.
Others have reported that this reduction in heart function is typically reversed when trastuzumab is discontinued, but in the anthracycline/trastuzumab arm in BCIRG 006, the decline in ejection fraction persisted beyond 550 days in most cases.
The good news regarding cardiotoxicity came from a BCIRG 006 substudy that suggests it may be possible through a simple genetic test to reduce cardiac risk by roughly two-thirds in patients with HER2-positive early breast cancer.
BCIRG 006 randomized 3,222 patients with HER2-positive breast cancer and positive lymph nodes or other high-risk features to one of three treatment arms: a control group given a standard potent anthracycline-based chemotherapy regimen consisting of four cycles of doxorubicin and cyclophosphamide followed by four of docetaxel, the same regimen with the addition of 1 year of adjuvant trastuzumab beginning concurrent with the docetaxel, or a year of trastuzumab starting at the outset of six cycles of docetaxel and carboplatin.
While others have reported that this reduction in heart function is typically reversed when trastuzumab is discontinued, that wasn't the case in patients in the anthracycline/trastuzumab arm in BCIRG 006; their decline in ejection fraction persisted beyond 550 days in most cases.
Testing needs to be completed on the remainder of the 3,222 BCIRG 006 patients, and other investigators will want to replicate these data before topo II testing becomes part of clinical practice, but "we're pretty confident that this is correct ...
Soldier 006 then claimed there was not enough room to lay the bodies side-by-side in the back of his army Land Rover.
CELEBRATED Sir Jackie J Stewart in his Tyrrell 006 at y the Goodwood Festival of Speed
He picked up XKC 006 from Jaguar's Browns Lane factory on July 8, 1952.
For the 1953 season, XKC 006 was joined by three other new C-Types when XKCs 041, 042 and 046 were delivered to the team's Merchiston Mews base for Jimmy Stewart, Ninian Sanderson and Sir James Scott-Douglas.
However, it was XKC 006 which was to prove the most consistent on the track, with another two wins, two seconds and three third placings secured during the 11-race season.