Although 1-hydroxybenzotriazole and its several derivatives are mostly used as peptide coupling reagents, their hazardous properties of explosiveness is not widely known.
The 1-hydroxybenzotriazole anhydrous industry has been explored in depth and aspects such as development history, landscape assessment, status of country-wise and regional developments, technological advances, and growth trends have been taken into consideration in this section.
The global 1-hydroxybenzotriazole anhydrous industry has been segmented on the basis of several important criteria such as application, technology, and geography.
The various marketing channels currently operating in the 1-hydroxybenzotriazole anhydrous industry have been identified and analyzed and aspects such as end-buyer price, regional imports and exports, marketing distributors, ex-work price, and channel price have been discussed in this segment.
The industry chain of the global 1-hydroxybenzotriazole anhydrous market has also been studied, with a detailed section on the important suppliers of manufacturing equipment, key suppliers of raw materials, and leading consumers.
The evaluation of the vendor landscape of the 1-hydroxybenzotriazole anhydrous industry is a valuable segment in the report as it deals with the most prominent players operating at a global and domestic level.
Abbreviation Ac-P1 to Ac-P4: N-Acetyl-pentapeptides [IC.sub.50]: Half maximal inhibitory concentration HQ: Dihydroxybenzene Phe: Phenylalanine AC: Acetyl group S: Serine R: Arginine F: Phenylalanine K: Lysine L-DOPA: L-3,4-Dihydroxyphenylalanine DMSO: Dimethyl sulfoxide MTT: 3-(4,5-Dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide [alpha]-MSH: Alpha-melanocyte-stimulating hormone PBS: Phosphate buffer solution TIS: Triisopropylsilane TFA: Trifluoroacetic acid Fmoc: 9-Fluorenylmethyloxycarbonyl- (Fmoc-) protected amino acids HBTU: 2-(1H-Benzotriazol-1-yl)-1,1,3,3- tetramethyluronium hexafluorophosphate HOBt: 1-Hydroxybenzotriazole
SPPS: Solid phase peptide synthesis DMEM: Dulbecco's modified Eagle's medium PS: Proline-serine VS: Valine-serine MCR-1: Melanocortin 1 receptor.
(200_) 2-chloro-N-hydroxyacetanilide 2-CNHA 2-chloro-6-methyl-N- hydroxyacetanilide CMNHA N-hydroxyacetanilide NHA N-hydroxybutyroylacetanilide NHB N-hydroxy-tert-butyroylacetanilide NHTB N-nitroso-N-phenylhydroxylamine NNPH Sigma Chemical N,N-dimethylformamide (used as a co-solvent) DMF 1-hydroxybenzotriazole
1-HBT Aldrich 3-hydroxy-1,2,3-benzotriazin-4- (3H)-one HBTO 1-hydroxyl-7-azabenzotriazole HABT N-hydroxyl-5-norbornene-2,3 dicarboxylic acidimide HNDAI 2-hydroxypyridine-1-oxide HPO N-hydroxyphthalimide NHPI ciclopirox olamine CPOA N-Benzoyl-N-phenylhydroxylamine BPHA Begtrup and Vedso 1-hydroxypyrazole HP (1995) 47hydroxy-2 H-1,4-benzoxazin-3-one HBA Atkinson et al.
Under N2 atmosphere adamantane-1- carboxylic acid (5.6 g 31.1 mmol) 1-ethyl-3-(3'-di methylaminopropyl)carbodiimide hydrochloride (8.9 g 46.7 mmol) 1-Hydroxybenzotriazole
hydrate (6.3 g 46.7 mmol) 4-dimethylamiopryidine (5.6 g 46.7 mmol) in 30 mL dried NN-Dimethylformamide was stirred at room temperature for 0.5 h a solution of 2-(45-diphenyl-1H-imidazol-1-yl)-N-(2-hydroxyethy l)acetamide (10.0 g 31.1 mmol) in 30 mL of dried NN-Dimethylformamide was added.