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CYP11B2 is located on chromosome 8q24 and catalyzes three reactions: the 11-hydroxylation of deoxycorticosterone (DOC) to corticosterone, the 18-hydroxylation of corticosterone to 18hydroxycorticosterone (18-OHB), and the 18-oxidation of 18hydroxycorticosterone to aldosterone [3,4].
CMO I is characterized by low levels of 18hydroxycorticosterone, whereas CMO II is characterized by high levels of 18-OHB and an increase of the urinary excretion of the major metabolite of 18-OHB [3].