Increased Incidence of Neoplasms in Rats Exposed to Low Levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin
. Chemosphere, 6(10): 625-632.
A critical review of the developmental toxicity and teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin
: recent advances toward understanding the mechanism.
Safe, "Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) on cell growth and the secretion of thee strogen-induced 34-, 52- and 160-kDa proteins in human breast cancer cells," Journal of Steroid Biochemistry and Molecular Biology, vol.
Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin
in the developing male Wistar(Han) rat.
Preliminary report: 2,3,7,8-tetrachlorodibenzo-p-dioxin
exposure to humans--Seveso, Italy.
Gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
disrupts B-cell lymphopoiesis and exacerbates autoimmune disease in 24-week-old SNF1 mice.
(TODD), an environmental pollutant, mediates toxicity through the aryl hydrocarbon receptor (AhR), a soluble, ligandactivated transcription factor.
For example, traces of 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) were identified in the fat of six workers contaminated during a 1953 chlorophenol explosion in West Germany.
Based on in vivo evidence of toxicity, the World Health Organization (WHO) assigned each congener a toxic equivalency factor (TEF), a measure of relative potency compared with that of reference chemical 2,3,7,8-tetrachlorodibenzo-p-dioxin
(Van den Berg et al.
(TCDD) is a potent environmental contaminant that elicits toxicity by activating the aryl hydrocarbon receptor.
AHR agonists, including both endogenous (e.g., several tryptophan catabolites), dietary (e.g., indole-3-carbinol metabolite indolo[3,2b] carbazole), and xenobiotic [e.g., 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD)] ligands, can dramatically impact host metabolism and immunity (Angrish et al.
The aryl hydrocarbon receptor (AhR) is a soluble receptor that mediates the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD), a potent and persistent environmental pollutant.