2-AAF2-Acetylamino Fluorene (pesticide)
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The decrease in 2-AAF production at 10 [micro]M quercetin glucuronides was possibly due to toxicity and loss of viable cells.
For instance, treatment of male rats with 2-AAF decreased the serum level of testosterone (22), whereas treatment with some carcinogenic hydrocarbons, such as 3-methylcholanthrene, 2-anthramine, and benzo[a]pyrene, markedly potentiated the androgenic effects of synthetic androgens given simultaneously (23).
Similar alterations have been reported in the pituitary from male rats one to several days after partial hepatectomy (40,41) and from the male rats receiving chronic feeding of liver carcinogen 2-AAF (12) or 3'-methyl-4-dimethylaminoazobenzene (42).
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