2-DG

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Acronym	Definition
2-DG	2-Deoxy-D-Glucose

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Focusing on energy-transfer, they measured the impact on cell lines in a laboratory of seven substances, the clinically-approved drug stiripentol, three natural products--caffeic acid phenyl ester (CAPE), silibinin, and ascorbic acid--and experimental pharmaceuticals, such as actinonin, FK866, and 2-DG.

Vitamin C Kills Cancer Stem Cells

Colonies were selected with clear zones of dissolved xylan in toxic 2-DG presence as catabolite repressor on agar screening plates containing Rose Bengal.

SHORT COMMUNICATION - Hyperexpression of xylanase from 2-deoxyglucose (2-DG) resistant mutant of Chaetomium thermophilum

Focusing on energy-transfer, they measured the impact on cell lines in a laboratory of 7 substances, the clinically-approved drag stiripentol, 3 natural products--caffeic acid phenyl ester (CAPE), silibinin and ascorbic acid--and experimental pharmaceuticals, such as actinonin, FK866 and 2-DG.

Vitamin C found effective in targeting cancer stem cells

Apoptosis was assessed by fluorescence-activated cell sorting (FACS) after treatment with MP and 2-DG or the combination of drugs.

2-Deoxy-D-glucose Restore Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia via Modification of N-Linked Glycosylation in an Oxygen Tension-Independent Manner

Fourth, explants cultured with normal glucose and insulin levels were treated for 24 h with 2-DG to block glycolysis and imitate alterations of glucose metabolism observed in certain forms of type 2 diabetes (Tab.

Organotypic retinal explant cultures as in vitro alternative for diabetic retinopathy studies

Specifically, experimental studies of neuronal gene therapy have demonstrated that induction of brain GLUT1 overexpression during ischemic insult was associated with a significant increase of glucose transport using 2-DG autoradiography [62], as well as improved neuronal survival [63, 64].

The potential roles of [sup.18]F-FDG-PET in management of acute stroke patients

Cells primed with 2-DG are then exposed to a pair of drugs, ABT-263/737, which signal the internal protein to initiate cell death.

New drug combo can provoke cancers cells to kill themselves

Clinical trials in patients with malignant brain tumours (glioblastoma multiforme) using a hypofractionted radiotherapy protocol combined with 2-DG have been very encouraging (134).

Cancer biomarkers--current perspectives

The research showed that vitamin C is upwards of 10 times more effective at halting cancer cell growth than other pharmaceutical treatments like 2-DG. The research team reports that the combination of vitamin C with an antibiotic proves about 100 times more effective at combating cancer than 2-DG.

Anti-aging medicine

SALFORD, England, March 8, 2017 - Vitamin C is up to ten times more effective at stopping cancer cell growth than pharmaceuticals such as 2-DG, according to scientists here.

Vitamin C found effective in targeting cancer stem cells

The glucose analogue 2-deoxy-D-glucose (2-DG) is metabolized by hexokinase and acts as an inhibitor of glycolysis [25].

Melatonin-Mediated Intracellular Insulin during 2-Deoxy-D-glucose Treatment Is Reduced through Autophagy and EDC3 Protein in Insulinoma INS-1E Cells

2-DG uptake is determined using an enzymatic assay.

Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes