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After first determining that in vitro cancer cells incubated with 2-DG and exposed to low concentrations of ABT-263/737 died, the researchers conducted animal studies.
Clinical trials in patients with malignant brain tumours (glioblastoma multiforme) using a hypofractionted radiotherapy protocol combined with 2-DG have been very encouraging (134).
Report results from a Phase 2 clinical trial of glufosfamide for first-line treatment of advanced pancreatic cancer during the third quarter; * Report top-line results from a Phase 1 clinical trial of 2-DG for treatment of solid tumors during the third quarter; * Initiate a Phase 2 clinical trial of glufosfamide in patients with previously treated advanced soft tissue sarcoma during the first half; * If the preclinical results are supportive, file an Investigational New Drug (IND) application for HAP-302 for solid tumors during the first half; and * Complete enrollment in the ovarian cancer, small-cell lung cancer and soft tissue sarcoma Phase 2 trials.