2-DG

Also found in: Medical.

Acronym	Definition
2-DG	2-Deoxy-D-Glucose

Suggest new definition

References in periodicals archive ?

Focusing on energy-transfer, they measured the impact on cell lines in a laboratory of 7 substances, the clinically-approved drag stiripentol, 3 natural products--caffeic acid phenyl ester (CAPE), silibinin and ascorbic acid--and experimental pharmaceuticals, such as actinonin, FK866 and 2-DG.

While they found that natural antibiotic actinonin and the compound FK866 were the most potent, the natural products also inhibited CSC formation, with vitamin C outperforming 2-DG by tenfold in terms of potency.

Vitamin C found effective in targeting cancer stem cells

The strongest increase in ONL cell death was observed after treatment with the glycolysis inhibitor 2-DG (Fig.

In the ONL, only the 2-DG treatment caused a significant reduction of nuclear rows (Fig.

Organotypic retinal explant cultures as in vitro alternative for diabetic retinopathy studies

Louis, MO, USA) and/or 2-DG (5 mM) (Sigma-Aldrich) for 24 hr, or with rapamycin (20 to 80 nM) (Calbiochem, San Diego, MO, USA) for 24 hr.

We investigated whether 2-DG reduced insulin synthesis which had been increased by melatonin via autophagy in rat insulinoma INS-1E cells.

Melatonin-Mediated Intracellular Insulin during 2-Deoxy-D-glucose Treatment Is Reduced through Autophagy and EDC3 Protein in Insulinoma INS-1E Cells

Specifically, experimental studies of neuronal gene therapy have demonstrated that induction of brain GLUT1 overexpression during ischemic insult was associated with a significant increase of glucose transport using 2-DG autoradiography [62], as well as improved neuronal survival [63, 64].

The potential roles of [sup.18]F-FDG-PET in management of acute stroke patients

After first determining that in vitro cancer cells incubated with 2-DG and exposed to low concentrations of ABT-263/737 died, the researchers conducted animal studies.

They found that when 2-DG was injected into animals, it predominantly accumulated in cancer cells that were subsequently killed by an injection of ABT-263/737.

New drug combo can provoke cancers cells to kill themselves

Clinical trials in patients with malignant brain tumours (glioblastoma multiforme) using a hypofractionted radiotherapy protocol combined with 2-DG have been very encouraging (134).

Effects of 2-DG on glycolysis, proliferation kinetics and radiation response of human cancer cells.

Cancer biomarkers--current perspectives

Chlorogenic acid, ferulic acid and berberine cause a modest, but significant, increase in 2-DG transport into the L6 myotubes and their performance is comparable to both the commercial oral hypoglycemic drugs.

Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes