2-DG


Also found in: Medical.
AcronymDefinition
2-DG2-Deoxy-D-Glucose
References in periodicals archive ?
Focusing on energy-transfer, they measured the impact on cell lines in a laboratory of seven substances, the clinically-approved drug stiripentol, three natural products--caffeic acid phenyl ester (CAPE), silibinin, and ascorbic acid--and experimental pharmaceuticals, such as actinonin, FK866, and 2-DG.
Colonies were selected with clear zones of dissolved xylan in toxic 2-DG presence as catabolite repressor on agar screening plates containing Rose Bengal.
Focusing on energy-transfer, they measured the impact on cell lines in a laboratory of 7 substances, the clinically-approved drag stiripentol, 3 natural products--caffeic acid phenyl ester (CAPE), silibinin and ascorbic acid--and experimental pharmaceuticals, such as actinonin, FK866 and 2-DG.
Apoptosis was assessed by fluorescence-activated cell sorting (FACS) after treatment with MP and 2-DG or the combination of drugs.
Fourth, explants cultured with normal glucose and insulin levels were treated for 24 h with 2-DG to block glycolysis and imitate alterations of glucose metabolism observed in certain forms of type 2 diabetes (Tab.
Specifically, experimental studies of neuronal gene therapy have demonstrated that induction of brain GLUT1 overexpression during ischemic insult was associated with a significant increase of glucose transport using 2-DG autoradiography [62], as well as improved neuronal survival [63, 64].
Cells primed with 2-DG are then exposed to a pair of drugs, ABT-263/737, which signal the internal protein to initiate cell death.
Clinical trials in patients with malignant brain tumours (glioblastoma multiforme) using a hypofractionted radiotherapy protocol combined with 2-DG have been very encouraging (134).
The research showed that vitamin C is upwards of 10 times more effective at halting cancer cell growth than other pharmaceutical treatments like 2-DG. The research team reports that the combination of vitamin C with an antibiotic proves about 100 times more effective at combating cancer than 2-DG.
SALFORD, England, March 8, 2017 - Vitamin C is up to ten times more effective at stopping cancer cell growth than pharmaceuticals such as 2-DG, according to scientists here.
The glucose analogue 2-deoxy-D-glucose (2-DG) is metabolized by hexokinase and acts as an inhibitor of glycolysis [25].