Previous studies have shown that LDL-C--lowering alleles in 3-hydroxy-3-methylglutaryl-CoA reductase
(HMGCR),  the gene encoding the target of statins, are associated with lower risk of coronary heart disease (CHD), but also an increased risk of T2D.
copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase
kinase activities," European Journal of Biochemistry/FEBS, vol.
Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy-3-methylglutaryl-CoA reductase
and acyl CoA: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids.
Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase
inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells.
The lobster mandibular organ produces soluble and membrane-bound forms of 3-hydroxy-3-methylglutaryl-CoA reductase
Micro assay for 3-hydroxy-3-methylglutaryl-CoA reductase
in rat liver and in L-cell fibroblasts.
The primary goal was to inhibit the enzyme 3-hydroxy-3-methylglutaryl-CoA reductase
(HMGR) responsible for cholesterol biosynthesis in the body.
This question is particularly relevant as the expression of the low-density lipoprotein receptor that is responsible for the intracellular uptake of cholesterol is regulated by mTOR,[sup.56] an active signaling pathway in RCC.[sup.57] Statins are synthetic agents that inhibit the rate-limiting enzyme of the mevalonate pathway, 3-hydroxy-3-methylglutaryl-CoA reductase
, thereby inhibiting cholesterol biosynthesis.[sup.58] Recently, it has been suggested that statins may have activity against RCC.
HMG-CoA reductase (or 3-hydroxy-3-methylglutaryl-CoA reductase
or HMGR) is the rate controlling enzyme (EC 184.108.40.206) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids.
Genes spotted multiple times on different parts of the array include 3-hydroxy-3-methylglutaryl-CoA reductase
, glycosylate reductase, choriogenin 2, a clone that shares homology to Unknown protein (GenBank accession no.
Several loci have been associated with LDL-c lowering: apolipoprotein E (APOE),  a solute carrier organic anion transporter family member 1B1 (SLC01B1), lipoprotein(a) (LPA), and sortilin 1 (S0RT1); other genes with inconsistent associations with LDL-c response include ATP binding cassette subfamily B member 1 (ABCB1), ATP binding cassette subfamily G member 2 (ABCG2), and 3-hydroxy-3-methylglutaryl-CoA reductase
(HMGCR), though these will not be covered here.
Partial cloning, tissue distribution and effects of epigallocatechin gallate on hepatic 3-hydroxy-3-methylglutaryl-CoA reductase
mRNA transcripts in goldfish ( Carassius auratus ).