3-NP3-Nitroproprionic Acid (biomedical)
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The pomegranate oil on 3-nitro propionic acid (3-NP) induced cytotoxicity in rat pheochromocytoma (PC-12) neuronal cells enhanced the levels of enzymatic and nonenzymatic antioxidants by neutralising ROS or enhancing the expression of the antioxidant genes [89].
Among them, transgenic models of HD, R6-lines (R6/1 and R6/2) [93, 94], knock-in YAC128 mouse model [95], and rats or mouse injected with acute and toxic quinolinic acid [96] and 3-NP [97] have extensively been validated.
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