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3TCLamivudine (GlaxoSmithKline)
3TCDideoxythiacytidine (antiviral drug)
References in periodicals archive ?
Breastfeeding women who are stable on individual TDF, 3TC and EFV should be changed to the FDC if they agree to do so.
For 3TC and d4T, the mobile phase was a mixture of 10 mM phosphate buffer, pH 6.
Patients who are co-infected with hepatitis B and HIV should normally be treated with TDF and 3TC or FTC, even if there is evidence of mutation in the HIV genome associated with resistance to these agents [60].
The response rate among patients not receiving 3TC or FTC in their background treatment regimen was 80% versus 25% on placebo.
Patients took only two pills each morning--one of TDF and one of Trizivir (TZV), which contains ABC, 3TC, and AZT.
The study, conducted in Uganda, revealed that 78% of patients currently taking 3TC had virus that was resistant to the drug.
Both the 600mg and 800mg BID doses of ATC, in combination with optimised background antiretroviral therapy (ART), showed superior antiviral activity to 3TC in a population of treatment-experienced HIV-1-infected patients with the M184V mutation which included both first-line failures and patients with multiple prior treatment failures.
Thirty-four-year-old Craig Smith had no choice but to go to Glaxo Welcome for a free supply of the anti-AIDS drug 3TC because neither he nor California's AIDS Drug Assistance Program could afford the drug.
9 kg kg kg AZT 60 1 1 1 AZT(new annexE) 300;10 mg/ml 6 ml 6 ml 6 ml AZT/3TC 60/30 1 1 1 AZT/3TC/NVP 60/30/50 1 1 1 ABC 60 1 1 1 ABC (new annexE) 300; 20 mg/ml 3 ml 3 ml 3 ml ABC/3TC 60/30 1 1 1 ABC/3TC/NVP 60/30/50 1 1 1 ABC/AZT/3TC 60/60/30 1 1 1 3TC 30 1 1 1 3TC (new annexE) 150;10 mg/ml 3 ml 3 ml 3 ml d4T 6 1 1 1 d4T(new annexE) various; 1 mg/ml 6 ml 6 ml 6 ml d4T/3TC 6/30 1 1 1 d4T/3TC/NVP 6/30/50 1 1 1 NVP 50 1 1 1 NVP (new annexE) 200; 10 mg/ml 5 ml 5 ml 5 ml Lopinavir/ 100/25 n/r n/r n/r ritonavir Lop/rit 80/20 mg/ml 1 ml 1.
The importance of fixed-dose combinations, and the reason there are now two more of them, is that several years ago, when AZT and 3TC were separate pills, Glaxo asked clinicians what they thought about putting them into one pill.
In addition, ZDV and 3TC caused fewer adverse effects than combinations with different nucleoside reverse transcriptase inhibitors, didanosine (ddI) and stavudine (d4T).