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5-ASA5-Aminosalicylic Acid (anti-inflammatory drug)
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Treatment with 5-ASA and CHCR prevented this target from modulating the progression of colitis (table 2).
Compounds based on premix alone, premix with 5-ASA, premix with 6 wt% of halloysites and premix with 5-ASA encapsulated HNT were then processed in a twin-screw extruder (Haake Rheomex PTW 16 OS, Thermo Scientific, Germany) at a screw speed of 60 rpm.
Although 5-ASA is commonly imputed as a cause, 9 reported patients were not on 5-ASA therapy, and these cases mostly occurred during flare up of the bowel disease (Table).
6) Traditionally 5-ASAs have been given as multiple doses 2 - 3 times daily, resulting in poor patient compliance.
The addition of antibiotics did not reduce the odds of a disease flare in the children who started therapy with 5-ASA, suggesting that pediatric Crohn's patients can be managed with fewer medications.
Analysis of the 5-ASA Subsegment of the Inflammatory Bowel Disease Prescription Pharmaceuticals Segment
Simultaneously, new data from the CONTRIBUTE trial showed that adding CORTIMENTAMMXA 9 mg was significantly more effective than placebo at inducing combined clinical and endoscopic remission in patients with ulcerative colitis experiencing a flare up despite oral 5-ASA therapy.
This randomised, double-blind, placebo-controlled Phase IIIb clinical study will evaluate whether there is an incremental benefit when UCERIS 9 mg is added to current oral aminosalicylate (5-ASA) therapy for patients with mild or moderate active ulcerative colitis who are not adequately controlled on background 5-ASA therapy.
Most patients (89%) reported that they would be interested in trying a once daily 5-ASA medication.
Two other agents in this class, balsalazide (Colazal) and olsalazine (Dipentum), are broken down in the colon to 5-ASA.
In more serious cases, treatment with sulfasalazine, 5-ASA drugs, and corticosteroids may be required.
Patients with inactive UC and CD were treated with 5-ASA and 5-ASA plus the immunosuppressor azathioprine, respectively.
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