5-FU


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AcronymDefinition
5-FU5-Fluorouracil (drug used against pancreatic cancer)
References in periodicals archive ?
Hamsters were randomly assigned into six groups (n=6/ group): Control group: injected with 0.9 % saline (5 mL/kg, sc, daily for 9 days); Mechanical trauma: animals subjected to scratches (mechanical trauma of the right cheek pouch) on day 4 and treated with 0.9% saline (5 mL/kg, sc , from day 1 to 9); 5-FU: intraperitoneal injection of 5-FU (60 and 40 mg/kg, respectively, on days 1 and 2), subjected to scratches (mechanical trauma of the right cheek pouch) on day 4, and treated with 0.9% saline (5 mL/kg, sc, from day 1 to 9); amifostine (AMF): intraperitoneal injection of 5-FU (60 and 40 mg/kg, respectively, on days 1 and 2), subjected to scratches (mechanical trauma of the right cheek pouch) on day 4, and treated with 12.5, 25, or 25 mg/kg AMF, sc, from day 1 to 9.
Grape seed extract (GSE) was used as a positive control as it was shown to be non-toxic to IEC-6 cells in low doses and to protect against 5-FU (18).
Pain related to treatment, side effects and cost can be determining factors in choosing a therapy.9 5-Fluorouracil (FU) is an antimetabolite that suppresses cell division and causes cell cycle arrest.10 Topical 5-FU is used in the treatment of warts but is not very effective.11 Intralesional injection of 5-FU permits higher drug concentrations throughout the lesion and previous study has shown it effectiveness in treatment of warts.12
Cytotoxic activity of extract was lower than fucoxanthin and 5-FU, while n-hexane and etyl acetate fraction seem higher than 5-FU but still lower than fucoxanthin.
A 34-year-old patient male patient was diagnosed with CA esophagus well differentiated keratinizing cell CA, he was admitted for the chemotherapy with cisplatin and 5-FU. He tolerated the treatment well, with no major complaints.
The human fibroblasts were plated in 96-well plates and exposed to AgNPs, AgNPs + 5-FU, 5-FU, and Annona muricata.
This study evaluated the safety and effect of a single subconjunctival injection of BVZ combined with 5-Fu or MMC on the antiscarring effect of GFS and compared them with the use of uncombined agents in in vitro and animal experiments.
In this work, 5-fluorouracil (5-Fu) with the molecular size of 5.3 x 5.0 [[Angstrom].sup.2] was chosen as the guest molecules because it is a widely used drug molecule for the cancer treatment.
Licofelone (Cayman) and 5-Fluorouracil (5-FU, Sigma) were first dissolved in dimethyl sulfoxide (DMSO, Sigma) and diluted further with Dulbecco's modified Eagle's medium (DMEM, Sigma) to obtain required final concentrations.
5-FU and S-1 are the most widely used fluorouracil and there are some differences between their components and pharmacological effects.