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5-HT5-Hydroxytryptamine (serotonin)
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20,21] Although imipramine, a tricyclic antidepressant with 5-HT and NE reuptake properties, has shown efficacy for post-prostatectomy incontinence, doses required to achieve success have significant anticholinergic side effects.
Immunofluorescence staining showed that GABA immunoreactivity and 5-HT immunoreactivity were present in different cells, but were also both present in some cells, of the cerebral, pleuropedal, and visceral ganglia.
Additional research is necessary to understand the complex function of the 5-HT system.
These data may support the idea that the 5-HT system is altered in the brain of OCD patients depending upon severity.
In particular, circulating Trp and 5-HT levels recovered along with the recovery of patients.
24-27 Conversely, 5-HT facilitates the secretion of glucagon from the alpha cells into the blood stream.
Previous electrochemical measurements of spinal 5-HT release by NRM stimulation indicate that this stimulus liberates a high level of 5-HT and that the 5-minute rest allows the activated neurons time for recovery [31].
Our unique genetic mouse models have revealed that POMC neurons are physiologically important targets of potent anorexigenic 5-HT compounds such as d-fenfluramine to suppress appetite," said Elmquist.
Other 5-HT reuptake inhibitory agents (fluoxetine) and NOS inhibitors have been shown to reduce the signs of ethanol withdrawal syndrome suggesting that this may be how HPE works.
The placebo group experienced none of these benefits except a slight decrease in triglycerides and an increase in 5-HT.