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5-HT5-Hydroxytryptamine (serotonin)
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The researchers found that for seizures without ICA, postictal serum 5-HT levels were increased over interictal levels compared with seizures with ICA.
In addition, manipulation of 5-HT during early development produces a reduction of tryptophan hydroxylase expression in midline subgroups of the raphe nuclear complex and a reduction in the density of Serotonin immunoreactive fibers in cortex (Weaver et al., 2010), and disturbs characteristic chemoarchitectural and electrophysiological brain features, including changes in raphe and callosal connections, sensory processing, and myelin sheath formation (Simpson et al., 2011).
Effects of U46619 on contractions to 5-HT, sumatriptan and methysergide in canine coronary artery and saphenous vein in vitro.
To test the effect of para-chlorophenilalanine (pCPA, Sigma), a 5-HT synthesis inhibitor, 48-hpf veligers were maintained in 50 ml of FW containing [10.sup.-5] mol [I.sup.-1] pCPA for 6 h at 22 [degrees]C.
As a key neurotransmitter in the pathophysiology of migraines, 5-HT is found at low levels in patients with chronic daily headaches (26).
The dose of PCPA (500 mg/kg) was selected based on evidence that PCPA remarkably decreases brain and serum 5-HT levels in mice [5, 6].
This plasticity could be related to changes in 5-HT receptors in MNs; 5-[HT.sub.2A] receptor mRNA increased after injury and increased further after passive cycling [42].
Pineal glands were analysed for 5-HT and 5-hydroxyl-indole3-acetic acid (5-H1AA) contents using HPLC with electrochemical detection.