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5-HT5-Hydroxytryptamine (serotonin)
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On the other hand, the raw data on the concentration of 5-HT and 5-HIAA as well as the expression of genes and proteins, after passing normality and homogeneity of variances tests, were subjected to a two-way ANOVA to determine any significant influences of the two parameters (photoperiod and LPS-treatment), followed by Fisher's least significant difference post-hoc test.
The release of 5-HT into the synaptic cleft leads to the binding of the neurotransmitter to one of its fifteen receptors (divided into 7 families), thus triggering physiological responses (22).
This study was designed to provide such data by analyzing the levels of 5-HT, 5-HT[sub]2A receptors (5-HT[sub]2AR), and SERT in the rat models of psychocardiological disease, which were pretreated with XinLingWan, sertraline, or saline.
The TDO enzyme activity is inversely proportional to the brain 5-HT concentration and/or turnover has been documented under many circumstances [21, 22, 23].
Furthermore, we characterized their combined effects on extracellular levels of DA and 5-HT in the mouse NAc shell.
Increase in brain 5-HT depends on the increase in brain tryptophan as the enzyme tryptophan hydroxylase is half saturated with its substrate [24].
From 5-HT and NE pathways to glutamate NMDA receptors
Furthermore the response of 5-HT receptors may be influenced by the aerobic capacity of an individual.
Studies report that clozapine, olanzapine, risperidone, paliperidone, and quetiapine improve sleep quality through their antagonistic effects on several receptors in the central nervous system, including the 5-HT (5-HT1 and 5HT2), dopamine (D1 and D2), histamine (H1), and noradrenaline ([alpha]l and [alpha]2) receptors [8,9] In 1990, Sharpley and colleagues [9] discovered a dose-response relationship between the dosage of medications that antagonize 5-HT2C receptors and increases in Stage III NREMS (i.