5-HTTLPR5-HydroxyTryptamine (serotonin) Transporter Gene-Linked Polymorphic Region
5-HTTLPRSerotonin-Transporter-Linked Promoter Region (neuroscience)
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7] A recent meta-analysis included a total of 1991 participants with OCD and their 5-HTTLPR allele status was examined.
The influence of family structure, the TPH2 G-703T and the 5-HTTLPR serotonergic genes upon affective problems in children aged 10-14 years.
For the 5-HTTLPR polymorphism, a fragment of 528 bp was observed for the insertion L/L homozygote genotype, two fragments of 484 bp and 528 bp for the heterozygote S/L, and one 484 bp fragment for deletion genotype S/S.
sup][9],[10] A 44 base pair insertion/deletion polymorphism ( 5-HTTLPR ) in the promoter region has been described for this gene.
The 5-HTTLPR gene is involved in regulating serotonin, a brain chemical implicated in depression and anxiety.
Investigar se o 99 adultos mais (2012) (66) alelo 5-HTTLPR esta velhos da associado a pobre comunidade.
De Neve found that individuals satisfied or very satisfied with life have a statistically significant higher percentage of this genotype (long 5-HTTLPR homozygous), compared to people dissatisfied with life.
To examine whether certain subgroups respond better to ondansetron, Johnson and colleagues (2011) tested ondansetron in two subgroups of alcoholics based on their genotype for the serotonin transporter gene SLC6A4-promoter region functional polymorphism 5-HTTLPR (L/S).
Influence of life stress on depression: moderation by a polymorphism in the 5-HTTLPR gene.
9,10,11,12) Analyzing data from 2,574 American students, De Neve found that individuals with the transcriptionally more efficient long allele of the 5-HTTLPR gene reported substantially higher levels of happiness, as measured by life satisfaction, than did individuals with the short allele.