5-HTTLPR5-HydroxyTryptamine (serotonin) Transporter Gene-Linked Polymorphic Region
5-HTTLPRSerotonin-Transporter-Linked Promoter Region (neuroscience)
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The (2010) statistic is a measure of the prevalence of the S-Allele in the polymorphism 5-HTTLPR of the serotonin transporter gene SLC6A4.
SLC6A4 17qll.l2 El alelo corto en el sitio polimorfico 5-HTTLPR localizado en el promotor del gen SLCA4 esta significativamente asociado con un aumento en el riesgo para toda la vida de desarrollar un s indrome depresivo en individuos con psicosis ([OR]=2.18).
Additive effects of 5-HTTLPR (serotonin transporter) and tryptophan hydroxylase 2 G-703T gene polymorphisms on the clinical response to Citalopram among children and adolescents with depression and anxiety disorders.
Brain Correlates of the Interaction Between 5-HTTLPR and Psychosocial Stress Mediating Attention Deficit Hyperactivity Disorder Severity.
Since psychological and genetic factors influence RAS pathogenesis, the aim of the present study was to evaluate 5-HTTLPR polymorphism in 5-HTT gene in patients with RAS in comparison to that in healthy subjects.
In BD, important genetic variants that could be affected by shiftwork either directly or indirectly are Del, ANK3 rs1938526, COMT Val158Met, DAOA, BRD1/ ZBED4, BDNF Val66Met, BRD1, ASMT, CAMTA1, CCDC132, CHES1, DGKH, DRD4, HTR1A C1019G, SLC6A4, 5-HTTLPR PARD3B, PDLIM5, STin2 VNTR, KLHL3, LYPD5, MAOA T941G, MTHFR A1298C and C677T, TPH1 STAB1, HTR3B, and WNK2 [95].
Amongst the most studied is a polymorphism in the promoter region (5-HTTLPR) of the serotonin transporter gene (SLC6A4) commonly reported with two variants: the l (long) allele, linked to increased concentrations of 5-HTT messenger RNA and increased serotonin (5-HT) uptake, and the s (short) allele, associated with decreased 5-HT uptake (11).
Effects of acute psychological stress exposure on endocrine and affective reactivity in college students differing in the 5-HTTLPR genotype and trait neuroticism.
Finally, worthy of note is that the research suggests that both the genotype of the serotonin transporter-linked polymorphic region (5-HTTLPR) status and TBI, independently, in almost identical but opposite ways affect the resilience and the perceived limitations of social participation.
A 5-HTT linked polymorphic region (5-HTTLPR) has two common variants, short (S) and long (L).
in their article "LinkPolymorphism of 5-HTT Promoter Region Is Associated with Autoantibodies in Patients with Systemic Lupus Erythematosus" found the frequency of SS genotype and S allele of serotonin transporter-linked polymorphic region (5HTTLPR) in SLE patients with positive anti-Sm antibody and anti-U1RNP antibody significantly higher than the other genotypes and allele and speculated 5-HTTLPR affecting production of some autoantibodies, especially anti-Sm and anti-U1RNP antibody in SLE.
Ismail, "Genetic association analysis of serotonin transporter polymorphism (5-HTTLPR) with type 2 diabetes patients of Pakistani population," Diabetes Research and Clinical Practice, vol.