A polymorphism in the serotonin transporter promoter gene 5-HTTLPR
has been associated with SAD.
Keywords: Adolescent, sexual abuse, 5-HTTLPR
, polymorphism, resilience
7] A recent meta-analysis included a total of 1991 participants with OCD and their 5-HTTLPR
allele status was examined.
The influence of family structure, the TPH2 G-703T and the 5-HTTLPR
serotonergic genes upon affective problems in children aged 10-14 years.
For the 5-HTTLPR
polymorphism, a fragment of 528 bp was observed for the insertion L/L homozygote genotype, two fragments of 484 bp and 528 bp for the heterozygote S/L, and one 484 bp fragment for deletion genotype S/S.
sup], A 44 base pair insertion/deletion polymorphism ( 5-HTTLPR
) in the promoter region has been described for this gene.
gene is involved in regulating serotonin, a brain chemical implicated in depression and anxiety.
Investigar se o 99 adultos mais (2012) (66) alelo 5-HTTLPR
esta velhos da associado a pobre comunidade.
De Neve found that individuals satisfied or very satisfied with life have a statistically significant higher percentage of this genotype (long 5-HTTLPR
homozygous), compared to people dissatisfied with life.
To examine whether certain subgroups respond better to ondansetron, Johnson and colleagues (2011) tested ondansetron in two subgroups of alcoholics based on their genotype for the serotonin transporter gene SLC6A4-promoter region functional polymorphism 5-HTTLPR
Influence of life stress on depression: moderation by a polymorphism in the 5-HTTLPR
9,10,11,12) Analyzing data from 2,574 American students, De Neve found that individuals with the transcriptionally more efficient long allele of the 5-HTTLPR
gene reported substantially higher levels of happiness, as measured by life satisfaction, than did individuals with the short allele.