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5-FC5-Fluorocytosine (antifungal agent)
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Toca FC is an orally administered prodrug, 5-fluorocytosine, which is converted into an anti-cancer drug, 5-fluorouracil, when it encounters CD.
Drug susceptibility was assessed using FUNGITEST[R] (Sanofi Diagnostics Pasteur) for the analysis of the growth of yeast-like fungi in the presence of six drugs: 5-fluorocytosine, amphotericin B, miconazole, ketoconazole, itraconazole, and fluconazole used at two concentrations, in modified RPMI 1640 medium, in the presence of a redox indicator.
The genetic basis of resistance to 5-fluorocytosine in Candida species and Cryptococcus neoformans.
Opaque cells reported to be more resistance to amphotericin B, nystatin, 5-fluorocytosine, and miconazole nitrate than white cells.
Treatment of experimental cryptococcal meningitis with amphotericin B, 5-fluorocytosine and ketoconazole.
Development of a recombinant Leishmania major strain sensitive to ganciclovir and 5-fluorocytosine for use as a live vaccine challenge in clinical trials.
Isolate Resistant (MIC) Intermediate (MIC) Scedosporium 5-Fluorocytosine (>64), apiospermum amphotericin B (>16), caspofungin (>8), None micafungin (>8), terbinafine (>2) Candida tropicalis None None Candida glabrata None None Isolate Susceptible (MIC) Scedosporium apiospermum Voriconazole (1) Caspofungin ([less than or equal to] 0.
Pharmacokinetics, outcome of treatment, and toxic effects of amphotericin B and 5-fluorocytosine in neonates.
Antifungal drugs such as ketoconazole, itraconazole, amphotericin B, and 5-fluorocytosine are ineffective.
In 1999, Oliva and colleagues successfully treated a patient with widely disseminated acanthamoebiasis following a single lung transplant for sarcoidosis with a combination of pentamidine, 5-fluorocytosine, itraconazole, and topical chlorhexidine gluconate-ketoconazole cream for skin lesions.
Anaerobic bacteria as a delivery system for cancer gene therapy: in vitro activation of 5-fluorocytosine by genetically engineered clostridia.