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The quest for more effective antiemetic drugs without sedative or extrapyramidal side-effects has led to the development of relatively new class of drugs 5-hydroxytryptamine antagonists.
The quantitative distribution of 5-hydroxytryptamine in the invertebrates, especially in their nervous systems.
The rhythmicity of molluscan cardiac muscle is regulated by numerous neurotransmitters and neuromodulatory agents, the most widely studied of these being the biogenic amine 5-hydroxytryptamine (5-HT), the tetrapeptide FMRF-amide, and acetylcholine (ACh).
All subjects had an established diagnosis of chronic or episodic cluster headache, described as headaches typically lasting 45 minutes or longer that were distinguishable from other types of episodic headaches, and had tolerated previous treatment with a 5-hydroxytryptamine (5-HT) agonist, such as sumatriptan or ergotamine.
ACTH could lead to a reduction in synthesis of central 5-hydroxytryptamine (5-HT) and noradrenaline (NE), and the reduced 5-HT and NE in the central nervous system is closely related to depression.
Acetylcholine (ACh), 5-hydroxytryptamine (5-HT), atropine, tropisetron and nifedipine were purchased from Sigma Co.
These include the atrial-selective agent AZD7009, gap junction modulators designed to restore pathologic defects in intercellular conduction, 5-hydroxytryptamine antagonists such as piboserod, and ATI-2042, a structural analog of amiodarone with similar electrophysiologic effects but less toxicity.
8%) cross-reactivity with six substances: secretin, spermidine, 5-hydroxytryptamine, bradykinin, estrogen, and calcitonin gene-related peptide.
Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine.
In animal tissues 5-HTP is metabolized by 5-HTP decarboxylase first to 5-hydroxytryptamine (5-HT) and then to 5-hydroxy-indole-3-acetic acid (5-HIAA).