Also found in: Dictionary, Thesaurus, Medical, Encyclopedia.
References in periodicals archive ?
AZA and 6-MP are inactive molecules that require bioactivation via a complex enzymatic metabolism.
A 38-year-old man with ulcerative colitis receiving 6-MP monotherapy underwent a liver biopsy for elevated aminotransferases.
Addressing these concerns, we recently conducted a meta-analysis of studies of women treated with azathioprine, and to a lesser extent, 6-MP, during pregnancy.
Studies have shown that 6-TGN levels are associated with clinical response when AZA or 6-MP is used in the treatment of Crohn's disease.
To our knowledge, reports evaluating potential differences between aza and 6-MP with regard to ITPA-related thiopurine intolerance have not been published.
In this series, patients homozygous for mutant low-TPMT-activity alleles tended to develop severe myelosuppression often and early, within the first 4-6 weeks on azathioprine or 6-MP.
TPMT irreversibly transfers a methyl group from S-adenosylmethionine (SAM) to 6-MP, forming 6-methylmercaptopurine (6-MeMP) and S-adenosylhomocysteine (SAH).
In the REACH trial, 112 patients (6 to 17 years of age; all required to be receiving 6-MP, AZA or MTX; 35% receiving corticosteroids) with moderate to severe, active Crohn's disease (median PCDAI of 40) and an inadequate response to conventional therapies received 5 mg/kg infliximab at weeks 0, 2, and 6.
The methyl 6-MP (Me6-MP) formed was measured using a modification of the HPLC procedure described previously (14).
In February 2006, REMICADE was approved in the EU for the treatment of moderately-to-severely active UC in patients who have had an inadequate response to conventional therapy, including corticosteroids and 6-MP or AZA, or who are intolerant to or have medical contraindications for such therapies.