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However, 6-MP or CYC did not have any effects on the LPS-induced release of IL-1[sz] (all P > 0.05; [Figure 1]c and [Figure 1]d).
6-MP dose was converted to an equivalent AZA dose by multiplying by 2.08 [13].
Data has shown that 6-MP was undetectable in the neonatal blood [21].
The thiopurines AZA and 6-MP are cytotoxic and immunosuppressive drugs that constitute the cornerstone ofmaintenance therapyfor inflammatorybowel disease (IBD).
Three cases of 6-MP hepatotoxicity were identified from the teaching case files of one of the authors, dating from 2007 to 2011.
Addressing these concerns, we recently conducted a meta-analysis of studies of women treated with azathioprine, and to a lesser extent, 6-MP, during pregnancy.
Background: Genetic polymorphisms in thiopurine methyltransferase (TPMT) influence the metabolism of azathioprine (AZA) and 6-mercaptopurine (6-MP) in patients with inflammatory bowel disease (IBD).
"The panel position was, however, cautious and mainly based on label recommendations despite an accumulation of evidence from databases on the safety of Aza / 6-MP [azathioprine / 6-mercaptopurine] and infliximab before conception and during the first trimester," researchers led by Dr.
(San Diego, CA), a specialty pharmaceutical company, announced that it has entered into a settlement agreement with Specialty Laboratories, Inc., whereby Specialty has agreed not to use, offer or sell its 6-MP Drug MonitR assay for use in connection with the treatment of immune-mediated gastrointestinal disorders or autoimmune diseases.
Among the 18 patients with intact colons, 14 (78%) received 6-mercaptopurine (6-MP) or azathioprine for an average of about 5.3 years: 6 patients started 6-MP/azathioprine a median of 21 months prior to beginning cyclosporine therapy, 6 patients began 6-MP/azathioprine during cyclosporine therapy, and 2 patients started 6-MP/azathioprine a median of 7 months after cyclosporine was stopped.
Azathioprine (Imuran) and 6-mercaptopurine (6-MP, marketed as Purinethol), which are metabolically identical, are the most widely used immunosuppressives for children.
Azathioprine (AZA) and 6-Mercaptopurine (6-MP), immunosuppressant agents that are used most commonly in organ transplant patients and patients with rheumatoid arthritis, have also shown to be efficacious in inflammatory bowel disease.