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Xia et al., "Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin," Oncogene, vol.
Szentirmai, "Regulation of specific activity of glucose-6-phosphate-dehydrogenase and 6-phosphogluconate dehydrogenase in Penicillium chrysogenum," FEMS Microbiology Letters, vol.
G6PD deficiency is the most common enzyme deficiency in humans and affects over400 million people worldwide.4 The glutathione pathway is paramount to antioxidant defense and G6PD-deficient cells do not cope well with oxidative damage.5 Normal values of G6PD 6-phosphogluconate dehydrogenase (6PGD) and glutathione reductase (GR) have been determined in normocytes reticulocytes newborn cord erythrocytes and leukocytes.6 Iron is a vital mineral that is widely encountered in biological systems.
G6PD catalyzes the conversion of glucose 6-phosphate to 6-phosphogluconate in the presence of NADP [7-10].
The majority of these expressed proteins were involved in glycolysis (enolase, fructose-bisphosphate aldolase, glyceraldehyde-3-phosphate dehydrogenase, L-lactate dehydrogenase, 6-phosphofructokinase, glucose-6-phosphate isomerase, phosphoglycerate kinase, phosphopyruvate hydratase, pyruvate kinase, triosephosphate isomerase, and 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase) and the remaining proteins were involved in fer-mentation (alcohol-acetaldehyde dehydrogenase, formate ace-tyltransferase, and pyruvate-formate lyase), the pentose phosphate pathway (6-phosphogluconate dehydrogenase [decarboxylating]), pyruvate decarboxylation (pyruvate dehydrogenase complex E2 component), and the urea cycle (ornithine carbamoyltransferase).
The activities of two major insulin induced enzymes, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase, in hexose monophosphate shunt are impaired, leading to reduced NADPH availability.
McKenna and Farrell (2010) used DNA sequences from 9 nuclear genes (elongation factor-1[alpha] (EF-1[alpha]), alanyl-tRNA synthetase (AATS), CAD, 6-phosphogluconate dehydrogenase (PGD), sans fille (SNF), triosephosphate isomerase (TPI), RNA Pol II, 28S, and 18S) to reconstruct the phylogeny of Holometabola with a focus on determining the phylogenetic placement of Strepsiptera.
All rely on the conversion by G6PD of glucose-6-phosphate to 6-phosphogluconate. In this reaction, G6PD uses NADP as a cofactor.
The conversion of UDP-glucose in a series of enzymatic steps to 6-phosphogluconate was coupled to [NADP.sup.+]-NADPH reduction with fluorescence detection.
The two strains differ by the mobility of a single isoenzyme 6-phosphogluconate dehydrogenase (6PGDH) as detected by isoenzyme characterization (15), which is considered as the gold standard in species diagnosis.
Apart from ALAD, (G6PD), an thiol containing first enzyme of the pentose phosphate pathway, that provides extra mitochondrial NADPH to the cells through the oxidation of glucose-6-phosphate to 6-phosphogluconate, which in turn provide the NADPH to maintain constant levels of GSH to GR, mediates the conversion of GSSG to GSH.
In Gelditsia triacanthos, isozyme-2 of 6-phosphogluconate dehydrogenase locus is an accurate predictor of sex in 5 natural populations.