TGN

(redirected from 6-Thioguanine Nucleotides)
AcronymDefinition
TGNTarragona (Catalonia, Spain)
TGNThesaurus of Geographic Names
TGNTrans-Golgi Network
TGNTotal Gaming Network
TGNThe Good News (Catholic Diocese of Kalamazoo newspaper)
TGN6-Thioguanine Nucleotides
TGNTask Group N (IEEE)
TGNTechnical Guidance Note (various organizations)
TGNTokyo Game Night
TGNThe Generations Network (various locations)
TGNThe Gamer Networks
TGNTrigeminal Neuralgia
TGNTelekom Global Net (T-Systems)
TGNTransport et Groupage du Nord (French: Transportation and Consolidation of the North)
TGNTrunk Group Number
TGNTasmanian Gaming Network
TGNTrade Games Now
TGNThe Gaming Nation
TGNTanzania Governance Noticeboard (Tanzania)
TGNTransporte de Gas del Norte
References in periodicals archive ?
Objective: The aim of this study is to assess the relationship between TPMT activity and 6-thioguanine nucleotide (6-TGN) and 6-methylmercaptopurine ribonucleotide (6-MMPN) levels in patients with 11313 in clinical practice.
Differences in nucleotide hydrolysis contribute to the differences between erythrocyte 6-thioguanine nucleotide concentrations determined by two widely used methods.
Azathioprine metabolism: pharmacokinetics of 6-mercaptopurine, 6-thiouric acid and 6-thioguanine nucleotides in renal transplant patients.
Analysis of 6-mercaptopurine, 6-thioguanine nucleotides, and 6-thiouric acid in biological fluids by high-performance liquid chromatography.
If patients with a homozygous deficiency of TPMT are given thiopurine derivatives at a standard therapeutic oral dosage, 6-thioguanine nucleotides will accumulate, usually within 4-6 weeks, to toxic concentrations.
Pharmacokinetics of 6-thioguanine nucleotides under i.v.
[1] Nonstandard abbreviations: 6-TGN, 6-thioguanine nucleotide; Me6-MP, 6-methylmercaptopurine; LC-MS, liquid chromatography--mass spectrometry; IR, infrared; NMR, nuclear magnetic resonance; and Me6-MPR, 6-methylmercaptoribonucleoside.
6-MP is further converted in the liver and gut to 6-thioguanine nucleotides, the pharmacologically active metabolites, by several enzymes, including hypoxanthine guanine phosphoribosyltransferase.