(redirected from 6-thioguanine)
Also found in: Dictionary, Thesaurus, Medical.
Category filter:
TGThe Great (band)
TGThe Game (online game)
TGTop Gear (British car show)
TGGlass Transition Temperature
TGTogo (top level domain)
TGTask Group
TGThe Gathering
TGThe Garden (Guns N' Roses song)
TGTop Gun (movie)
TGThank God
TGThat's Good
TGThat Guy
TGThai Airways International
TGThurgau (Thurgovie; Swiss Canton)
TGThe Gap
TGThinkGeek (website)
TGTop Girls (play by Caryl Churchill)
TGTexas Guaranteed (education)
TGTechnical Guide
TG6-Thioguanine (chemotherapy drug)
TGToo Good
TGThat's Great
TGThai Airways International (IATA Airport Code)
TGTagesgeld (German)
TGThe Gamers
TGThird Grade
TGToyoda Gosei Co., Ltd. (Japan)
TGTotal Girl (magazine)
TGThrobbing Gristle (1970s band)
TGTarget Group
TGTrigun (TV show)
TGTokyo Gas Co., Ltd. (Tokyo, Japan)
TGThermogravimetry (mass change study)
TGTerry Gilliam (director)
TGTwynstra Gudde (consulting firm; Netherlands)
TGTiefgarage (German: underground parking)
TGTraditional Grammar
TGTemperature Gradient
TGTopical Guide
TGTurbine Generator
TGTechnical Group
TGTail Gunner
TGTeragram (metric unit of mass)
TGTotal Guitar (magazine)
TGTrunk Group
TGTactical Gamer (online community)
TGTa Gueule (French: Shut Up)
TGTonenGeneral (oil company; Japan)
TGTrue Good (gaming)
TGTitan's Grip (World of Warcraft)
TGTrésorerie Générale (French: General Treasury)
TGTransmission Group
TGTransformational Grammar
TGTiming Generator
TGTransfer Guide (Maricopa County, AZ community college system)
TGTransformational-Generative (grammar)
TGTrinidad Guardian (Newspaper) (German software development company)
TGTogdheer (postal region, Somalia)
TGTaux de Gravité (French: Severity Rate)
TGTail Gating
TGTrunking Gateway
TGThompson Gun
TGTroop Guide (Boy Scouts of America)
TGTotino-Grace (Minnesota High School)
TGToy Guy
TGTask Graph
TGTwin Groves (Illinois, USA)
TGTransactions on Graphics
TGTrue Gravity
TGTail Grab (skiing and snowboarding)
TGTriple Glazing (windows)
TGTransmitter Group
TGTrinity Grammar (school)
TGTransaction Group
TGTote Gote (mini bike)
TGTanner Graph
TGTigre Géant (Canadian retailer)
TGTangent Galvanometer (physics)
TGTotal Gradient (gravity and magnetic)
TGTracking Gain
TGTrack Gate
TGTraffic Gateway
TGThermite Grenade
TGTactical Guard
TGTransformation Gateway (Net6)
TGTop of Grate (surveying)
TGTexas Gunmen (gaming group)
TGThomas Group Ltd (Orange, CA)
Copyright 1988-2018, All rights reserved.
References in periodicals archive ?
Bolton, "6-Thioguanine alters the structure and stability of duplex DNA and inhibits quadruplex DNA formation," Nucleic Acids Research, vol.
Acute sinusoidal obstruction syndrome after 6-thioguanine therapy for Crohn's disease.
As 6-mercaptopurine and 6-thioguanine have been used as effective anticancer and anti-inflammatory drugs it is worthwhile to explore modified thionucleobases.
Simultaneous determination of 6-thioguanine and methyl 6mercaptopurine nucleotides of azathioprine in red blood cells by HPLC.
determining the level of 6-thioguanine to a subject having said immune-mediated gastrointestinal disorder, wherein the level of 6-thioguanine in said subject, having said immune-mediated gastrointestinal disorder, wherein the level of 6-thioguanine less than about 230 pmol per 8x108 red blood cells indicates a need to increase the amount of said drug subsequently administered to said subject and wherein the level of 6-thioguanine greater than about 400 pmol per 8x 108 red blood cells indicates a need to decrease the amount of said drug susceptibility administered to said subject."
(a) administering a drug providing 6-thioguanine to a subject having said immune-mediated gastrointestinal disorder; and
Azathioprine, a derivative of 6-mercaptopurine, exhibits an impressive immunosuppressive effects and has been successfully used in rheumatoid arthritis, autoimmune bullous disorders, renal transplant patients and other autoimmune diseases.11,12 There is evidence to suggest that both the number and antigen-presenting capacity of Langerhan cells are affected by azathioprine, which prevents lymphocyte proliferation after antigenic stimulus.13 Although its exact mechanism of action is not known, the major immunosuppressive effect is thought to result from blocking of DNA replication due to incorporation of the azathioprine metabolite 6-thioguanine nucleotide.14
A more reproducible approach is to measure the metabolites 6-thioguanine (6-TGN) and 6 methylmer-captopurine (6-MMP).
Alternative systemic agents sometimes used for recalcitrant psoriasis management include hydroxyurea, sulfasalazine, azathioprine, mycophenolate mofetil, fumaric acid esters, 6-thioguanine and leflunomide.
Wiernik kindly responded: "I do not know of any five year or longer survivors of acute granulocytic [myelocytic] leukemia treated only with cytosine arabinoside and 6-thioguanine ..." It seems only reasonable, therefore, to attribute Patient #17's long-term survival to the Kelley program.
Objective: The aim of this study is to assess the relationship between TPMT activity and 6-thioguanine nucleotide (6-TGN) and 6-methylmercaptopurine ribonucleotide (6-MMPN) levels in patients with 11313 in clinical practice.