Cephalosporins are produced by having the key intermediate for semisynthetic production of a large number of cephalosporins which is 7-aminocephalosporanic acid
, which is formed by hydrolysis of cephalosporin C produced by fermentation.
Robert Morin discovered a process by which the D-[alpha]-amino adipoyl side chain of CPC could be removed, generating 7-aminocephalosporanic acid (7-ACA) in 1962 (2).
Both enzymes classes form 7-aminocephalosporanic acid (7-ACA) (11).
Overproduction and purification of glutaryl 7-aminocephalosporanic acid acylase, Prot.
In the pharmaceutical semisynthesis of cephalosporin derivatives, the central intermediate 7-aminocephalosporanic acid
(7-ACA) is obtained by enzymatic cleavage of the fermentation product cephalosporin C (CephC) .
for oxidation of cephalosporin C in the two-step formation of 7-aminocephalosporanic acid
 and for a human gene therapy paradigm that involves oxidant-mediated tumor cell death .
Single-Step Conversion of Cephalosporin-C to 7-Aminocephalosporanic Acid
by Free and Immobilized Cells of Pseudomonas diminuta.