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PR8A/Puerto Rico/8/34 (virus)
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However, an 11th protein, called PB1-F2, was found in A/Puerto Rico/8/34 (H1N1).
This new protein product was discovered serendipitously during a systematic search of potential antigenic peptides recognized by CD8+ T lymphocytes encoded by influenza virus A/Puerto Rico/8/34 (H1N1) (4).
A 561- to 564-nt HA sequence was obtained for H1N1 isolates from genomic position 120 to 683 of A/Puerto Rico/8/34 (H1N1), and an 844-nt sequence was obtained for H3N2 isolates from genomic position 187 to 1031 of A/Hong Kong/1/68 (H3N2).
The complete ORF for PB1-F2 in A/Puerto Rico/8/34 (H1N1) is from position 119 to 379, which encodes an 87-residue protein (4).
The putative PB1-F2 protein of A/Taiwan/3355/97 (H1N1) was 81.1% identical to A/Puerto Rico/8/34 (H1N1).
The putative full-length PB1-F2 of these Taiwanese strains contained 90 aa, which was three residues longer than A/Puerto Rico/8/34 (H1N1).
PB1-F2 of A/Puerto Rico/8/34 (H1N1) has been shown to localize to the mitochondria and induce cell death.
The only H1N1 isolate in 1997, A/Taiwan/3355/97, was found to encode the entire 90-residue PB1-F2 ORF, which is 3 aa longer than the PB1-F2 of A/Puerto Rico/8/34 (H1N1).