El receptor A1 (A1R) no es crucial para el efecto estimulante de la cafeina, pero parece modular el efecto de la cafeina ejercida a traves del bloqueo del receptor A2A (A2AR
antagonists: next generation checkpoint blockade for cancer immunotherapy," Computational and Structural Biotechnology Journal, vol.
Boia et al., "Adenosine A2AR
blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure," Journal of Neuroinflammation, vol.
In contrast, A2AR
could also participate in the inflammatory process in OB.
Taylor, "Both MC5r and A2Ar
are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice," The Journal of Immunology, vol.
Santiago, "denosine A2AR
blockade prevents retinal microglial activation," in Proceedings of the 22nd IUBMB 37th FEBS Congress, Blackwell, Seville, Spain, 2012.
In vitro study found that 2-Cl-IB-MECA was a potent A3AR agonist (Ki = 0.33 nM) with a 2500- and 1400-fold selectivity for A3AR versus A1AR and A2AR
, respectively [27, 28].